In this study, the protein levels of NLRP3, Caspase 1 p20, and IL‐1β in the myocardium of mice from the NR1H3‐KO + CLP group were significantly higher than those from the WT + CLP group, suggesting that NR1H3 deficiency could lead to activation of NLRP3 signaling pathways during sepsis (Figure 4a,b). This evidence concerns the gene CASP1 and Sepsis.