NLRP3 inflammasome assembly and activation can self‐cleavage to produce an active form of Caspase‐1 (pro‐Caspase‐1), promoting the release of proinflammatory cytokines including IL‐1β, IL‐18, and the alarmin high mobility group protein B1 (HMGB1), en route to inflammation of sepsis. This evidence concerns the gene HMGB1 and Sepsis.