In this trial, the neuroprotective effect of Clostridium butyricum‐pMTL007‐GLP‐1 (C. butyricum‐GLP‐1) was assessed in PD mice models and its underlying mechanism was explored via behavioral tests, immunohistochemistry, immunofluorescence, ultrastructural morphology, Western blotting, and 16S rDNA high throughput sequencing. This evidence concerns the gene GLP1R and Parkinson disease.