Albumin also interacts with receptors such as secreted protein acidic and rich in cysteine (SPARC) and glycoprotein 60 (gp60), which are overexpressed in endothelial cells undergoing increased neovascularisation as well as GBM tumor cells, thus allowing a larger number of albumin‐based NPs to infiltrate the tumor.58, 65, 66. This evidence concerns the gene ALB and neoplasm.