ACE and coronary artery disorder: Cambien and colleagues were the first to report an association between the ACE I/D genetic variant and the risk of AMI; the study sample from ECTIM (Etude Cas-Temoin de l'Infarctus du Myocarde) included 610 men aged 25–64 years who had survived for 3–9 months after AMI and 733 participants with no history of CAD (11).