According to the multiple regression analyses, 13 variables including age, sex, creatinine clearance, baseline SBP, hemoglobin, warfarin dose, heart failure, hypertension, diabetes mellitus, stroke/TIA, and use of angiotensin II receptor blocker (ARB) or angiotensin converting enzyme inhibitor (ACE-I), β-blocker, and Ca channel blocker were identified as factors associated with SBP-SD (Supplementary Table 1). This evidence concerns the gene ACE and hypertensive disorder.