Moreover, genes associated with immune response activation, including CD163, CD27, CD40, CXCL12, IDO1, LAMP3, LGALS9, NKG7, NOS1, TIMD4, TNFSF9, and TREM2, were downregulated in SRSF1 high expression MM patients, while genes related to immune response limitation such as LAIR1 and TNFRSF8 were upregulated in SRSF1 low expression MM patients. The gene discussed is TIMD4; the disease is Miyoshi myopathy.