FOXP3 and neoplasm: However, it is important to note that FOXP3+ TILs are a heterogeneous group that includes not only suppressive elements, but also a non-suppressive population with significant antitumor activity, which necessitates further investigation of the given issue and the definition of a clear opinion on the influence of Treg on tumor progression and treatment with immunotherapeutic methods (51, 52, 57–62).