The result of CIBERSORT revealed that the low-risk melanoma patients had significantly higher proportions of naive B cells, plasma cells, CD8 T cells, CD4 memory-activated T cells, regulatory T cells, and M1macrophages and considerably fewer resting NK cells, as well as M0 and M2 macrophages than the high-risk melanoma patients (Fig. 9A). This evidence concerns the gene CD4 and melanoma.