The eNOS is one interesting pro‐target for protection against hypertension and cardiovascular diseases, as it produces nitric oxide (NO), which protects vascular integrity by preventing platelet aggregation, and smooth muscle proliferation.[46] NO is usually produced from the oxidation of the l‐arginine to l‐citrulline by eNOS in the presence of the 5,6,7,8‐tetrahydro‐l‐biopterin (BH4) cofactor. The gene discussed is NOS3; the disease is Hypertension.