TLR4 and metabolic dysfunction-associated steatohepatitis: [251] Moreover, other microalga‐based active compounds—such as carotenoids, proteins, polysaccharides, triterpenoids, and phenolic compounds—may have an effect on receptors, including TLR4, TLR2, and TLR9.[118] Suppression of the TLR4, which binds LPS, and of TLR9, which binds DNA derived from intestinal bacteria, markedly attenuates the inflammatory phenotype in a number of experimental models of NAFLD/NASH.[185]