Significantly reduces disease activity index, the wet weight of the colon, the ulcer area, macroscopic grades and histological changes, effectively lowers myeloperoxidase and malondialdehyde levels, increases enzymatic activity of superoxide dismutase and catalase, increases glutathione levels, suppresses TNF‐α, IFN‐γ, IL‐6, IL‐1β, and NF‐κB levels, digestion of nitric oxide and COX2 protein expression. Here, CAT is linked to ulcer disease.