BRCA1 and BRCA2 are in the leading 30 of 236 markers that are highly frequently mutated in human papillomavirus-negative HNSCC, although other markers that are implicated in DNA destruction are also subject to genetic abnormalities in HNSCC, but at varying percentages (Chung et al., 2015). Here, BRCA2 is linked to head and neck squamous cell carcinoma.