A study of encapsulated curcumin-difluorinated (CDF) in liposomes investigated proliferation suppression in cisplatin-resistant HNSCC cell lines and reported that after treatment with CDF-encapsulated liposomes, the inhibition of growth in vitro and the production of cytokines, growth factors, and cancer stem cell markers (CD44) were examined. The gene discussed is CD44; the disease is head and neck squamous cell carcinoma.