STAT3 and neoplasm: Gab1 stimulation by phosphorylation triggers the upregulation of signal transducers and activators of transcription-3 (STAT3), SH2-containing protein tyrosine phosphatase (SHP2), and phosphoinositide 3-kinase (PI3K) whereas phosphorylation of Grb2 triggers the tumorigenic Raf/Ras pathway which results in tumor growth, multiplication, and migration (Figure 5) (Raj et al., 2022).