Nonetheless, accumulation of follicular CD8+ T cells (fCD8) has been associated with immune control of pathogenic viral infections and cancers, including LCMV (10–12), HIV (11– 16), SIV (17–21), EBV infectious mononucleosis (12, 22–24), B cell lymphoma (25–27) and HBV-related carcinoma (28), as well as lung (29), pancreatic (30) and colorectal cancers (31, 32). The gene discussed is CD8A; the disease is cancer.