NEC lymphatic endothelial cells, primarily interacted with leukocytes via cytokines and chemokines including: to macrophages via CCL3L1-CCR1 (Fig 6E), dendritic cells via CXCL9/CXCL10/CXCL11-CXCR3 and CCL20-CCR6 (Fig 6F), and naïve T cells via CXCL9/CXCL10/CXCL11-CXCR3 (Fig 6G). Here, CCR1 is linked to necrotizing enterocolitis.