A survey of a cancer dependency map (DepMap, https://depmap.org/portal/) revealed that most of the identified genes were compatible with the colon cancer cell lines obtained from DepMap and that the knockout of these genes (except for SLC7A6, SC5D, LSS, EBP, NSDHL, and SLC2A13) resulted in a high amount of cell death (Table 3). The gene discussed is LSS; the disease is malignant colon neoplasm.