Since cancer-related distress was shown to be higher in CRC survivors with advanced cancer stages [12], the high-stress levels in CRC survivors with advanced cancer stage might trigger stress-induced visceral pain by activating glucocorticoid receptor and corticotropin-releasing hormone-mediated mechanisms in the amygdala involved in stress-induced visceral hypersensitivity [30]. Here, CRH is linked to colorectal carcinoma.