In endometriotic cells, NK-κB signaling is activated by TNFα [12] [100] [101] [47] and the aberrant activation of NF-κB signaling leads to chronic inflammation, increased cell proliferation, and survival of ECs in endometriosis [102] [23] [24] [18] [19] [20], [21] [22]. The gene discussed is TNF; the disease is endometriosis.