PCB 126 was the most consistent congener associated with diabetes is plausible because it is the most potent dioxin-like PCB congener that can interact with the aryl hydrocarbon receptor (AhR), alter glucose transport and insulin tolerance in mice through an AhR-dependent mechanism33–35, and inhibit adipogenesis which leads to alteration in fatty acid metabolism36. The gene discussed is INS; the disease is diabetes mellitus.