Bulk RNA sequencing of suspension organoids at 3, 7, 10, and 14 days post-infection revealed up to 26-fold time dependent promotion of interferon-stimulated genes such as IFIT3, MX1 and MX2, consistent with an innate antiviral response47,48 (Fig. 5b, Extended Data Fig. 7c). The gene discussed is MX2; the disease is infection.