Accordingly, SARS-CoV-2 infection increased the prevalence of 4–1BB+CD25+, OX40+CD40L+ and OX40+CD25+ AIM marker double-positive CD8+ T cells in lung ALI organoids from seropositive and/or positive infection history donors, but not from the seronegative donor (Fig. 6a–b, Supplementary Table 1). Here, CD8A is linked to infection.