TGFBR2 and neoplasm: An Adenovirus 5 (Ad5)-based oncolytic virus expressing sTβRII-Fc fusion protein (Ad.sTβRFc) and a 01/07 based adenoviral vector expressing the soluble form of TβRII fused with human Fc IgG1 gene (mhTERTAd.sTβRFc) vectors can induce the secretion of TβRII-Fc into the tumor-bone microenvironment.