Various pathways such as β-catenin, tumor suppressor protein 53 (p53), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, also known as AKT) and mitogen-activated protein kinase (MAPK), have been implicated in the initiation, progression, and migration of colorectal cancer [16, 17]. The gene discussed is AKT1; the disease is colorectal cancer.