Despite the fact that CD25 Mab features an avidity driven binding to CD25 and as a consequence preferentially triggers the killing of cells with high levels of CD25 expression (17), the ADCC capacity of CD25 Mab with EOL-1 and AML-22 as target cells were comparable to that of CD25 high target cells (Figure 5B). Here, IL2RA is linked to acute myeloid leukemia.