EZH2 and neoplasm: Evasion of NK cell immune surveillance occurs via a circular EZH2 encoded protein (EZH2-92aa) that directly binds the promoters of genes (MICA/B, ULBP) necessary for the expression of NK group 2D ligands in GSCs, leading to decreased transcription and ultimately decreased NK cell-mediated tumor cell death (14, 139, 142, 143).