Comparison of periventricular human GBM to normal subventricular zone NSCs obtained from non-human primates suggested a potential role for the H4K20 methyltransferases KMT5B and KMT5C (Suv420H1/2) in GBM tumorigenesis, showing that 21-31% of genes repressed by the H4K20me3 mark in NSCs are upregulated in GBM cells (173). Here, KMT5B is linked to glioblastoma.