Separate research integrated this mark of active enhancer regions with gene expression and DNA methylation data to define the enhancer landscape within GBM, finding many of the concordant loci located at genes with important functions in stem cell maintenance, such as SOX2, EGFR, POU3F2, and SALL3. Further profiling of the H3K27ac landscape in primary tumor tissue samples revealed SOX2 to be a shared TF among all GBM subtypes and normal brain tissue, while POU3F2 was preferentially found in proneural tumor samples (201). This evidence concerns the gene SALL3 and neoplasm.