However, the expression of KDM6B in human GBM tumors is variable and heterogeneous, and contrasting research has suggested that overexpression of this enzyme inhibits neurosphere formation in vitro and tumor formation in vivo and further that STAT3-mediated repression of KDM6B expression is essential for neurosphere formation and cellular proliferation (121). The gene discussed is KDM6B; the disease is glioblastoma.