Studies evaluating their role in the setting of GBM have found increased expression of both genes compared to normal brain, and decreased cell proliferation, increased apoptosis, reduced migration, and reduced colony formation upon shRNA knockdown of SETDB1 or inhibition of Suv39H1 with chaetocin in established GBM cell lines (155, 156). The gene discussed is SUV39H1; the disease is glioblastoma.