Though comparatively less work has been done on the role of lysine acetyltransferases in GBM, expression of the lysine acetyltransferase KAT6A is upregulated in GBM, and its acetyltransferase activity promotes tumorigenesis through the regulation of PIK3CA expression and PI3K/AKT pathway activation (50). The gene discussed is AKT1; the disease is glioblastoma.