In addition, they identified that HNF4G targets G protein gamma 12 (GNG12) and protein tyrosine kinase 2 to activate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway and enhance cell proliferation in colorectal cancer (CRC) (PTK2). This evidence concerns the gene PTK2 and colorectal carcinoma.