WIF1 and malignant colon neoplasm: Ectopic production of miR-339 and specifically miR-766 has been shown to limit the growth of colon cancer by reducing the methylation that is in the tumor suppressor genes like Dickkopf-related protein 2 (DKK2), WNT inhibitory factor 1 (WIF1), secreted frizzled-related protein 1 (SFRP1), and SFRP2 (109).