SREBP-1 is an important regulator of hepatocellular carcinoma; tissue samples from patients with hepatocellular carcinoma with upregulated SREBP-1 were associated with poor outcomes, and corresponding in vitro experiments showed that downregulation of SREBP-1 led to increased numbers of apoptotic cells and inhibited cell proliferation (95). Here, SREBF1 is linked to hepatocellular carcinoma.