TP53 and cancer: The result showed that most of the pathways involved in metabolism, immunity, and cancer, including the TCA cycle, FC gamma R-mediated phagocytosis, Leukocyte transendothelial migration, T cell receptor signaling pathway, P53 signaling pathway, pathways in cancer, Notch signaling pathway, TGF beta signaling pathway, and ECM-receptor interaction, were significantly enriched in cluster B, which may contribute to the poorer prognosis (Figure 2E, Supplementary Figure S2N).