Interestingly, we found that pro-cuproptosis genes such as PDHB and SLC31A1 were lowly expressed in the high-risk group, while anti-cuproptosis genes such as GLS and CDKN2A were highly expressed in the high-risk group (23), indicating that PCa patients with high CRRS may be in an inhibited state of cuproptosis. Here, PDHB is linked to posterior cortical atrophy.