SACK1D and Familial prostate cancer: In addition, most of the model genes showed varying degrees of downregulation in the presence of Cu2+ and Elesclomol in most PCa cell lines, with B4GALNT4 and FAM83D being the most significant (Figures 11A-D, p<0.05), demonstrating the close association of these two genes with cuproptosis in prostate cancer cells.