With regard to SF, modules correlated to ANA negativity, oligoarticular course, no iridocyclitis, and no relapse were enriched in proteins related to ribonucleoprotein complex assembly, organization, and biogenesis, such as HNRNPs (150), which function as autoantigens (151–153) and have potential as targets of therapy in RA (154), and nuclear proteins acting in chromatin remodeling (e.g. HMGB1 and NCL). The gene discussed is HMGB1; the disease is iridocyclitis.