Other relevant EV-prots belonging to these modules were involved in the regulation of ECM organization and cell adhesion/migration (e.g. FN1 and NRP1) and in synovial inflammation, fibrosis, hyperplasia, angiogenesis, and/or joint degradation (e.g. CD109, CRTAC1, and LUM) and proposed as putative development/progression biomarkers or potential therapeutic targets in RA and/or OA (77, 158–162). The gene discussed is CD109; the disease is rheumatoid arthritis.