PMEL and melanoma: Given the frequent clinical observations that AA seems to target gray hairs rather than pigmented hairs and nonpigmented hair regrowth, melanocyte antigen epitopes have long been suspected as potential targets (139–143), such as tyrosinase (TYR), tyrosinase-related protein-1 (TRP-1), TRP-2, glucoprotein100 (gp100, premelanosome protein analog), Melan-A (also known as melanoma antigen recognized by T cells 1 Leu27 analog, MART-1), and melanocortin-1-receptor (MC1R) (140, 144).