In line with our previous results, the gene expression levels of key interleukins (IFNγ, TNFα, IL6, IL15, IL18, IDO1, and CSF1), chemokines and their receptors (CCR7, CCL19, CXCL9, CXCL10, CXCL11, CXCL12, CXCR4) (tumor/spleen fold change: 5.5e+01 to 5.1e+04 for M0; 1.0e+02 to 4.8e+06 for M1, p ≤0.01, respectively), and TLRs (TLR1, TLR2, TLR4, TLR5, TLR6, TLR8) (tumor/spleen fold change: 2.5e+04 to 5.1e+06 for M0; 2.9e+02 to 2.9e+06 for M1, p ≤1.0e-3, respectively) were significantly increased in M0 and M1 macrophages of DLBCL compared with spleen samples (Figures 5A–C and Tables 2, 3). This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.