INS and diabetes mellitus: More and more reports have found that monogenic diabetes with GATA6 mutation can manifest as diabetes in children or adults, with or without pancreatic developmental defects, which can be combined with heart defects, hepatobiliary defects Abnormalities such as muscle hernia, growth retardation, hypothyroidism, etc. Neonatal diabetes caused by GATA6 mutation is insulin dependence, but it is sensitive to insulin.