Our current data show that long-term exercise was able to counteract the iWAT inflammation that accompanies obesity and aging, as revealed by: i) the lower macrophages content (F4/80+/Cd11b+) in iWAT SVF; ii) the decrease observed in proinflammatory cytokines (Tnf, Il6); and iii) the increase in antiinflammatory adipocytokines Adiponectin (Adipoq) and Il4 mRNA levels. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.