Increased oxidative stress caused by accumulated fat, accompanied by an augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes (causing dysregulation of plasminogen activator inhibitor-1, TNF-α, resistin, leptin, adiponectin, and other adipocytokines), promotes the development of MetS Sinharoy et al. 2019. This evidence concerns the gene RETN and metabolic syndrome.