Compounds 131 and 132 showed interesting activity in response to colon cancer cell line HCT 116 (GI50 =  > 10 for compound 131, 5.1 ± 0.8 μM for compound 132 against HCT 116 p53+/+, GI50 = 6.5 ± 1.2 for compound 131, 6.1 ± 2.2 μM for compound 132 against HCT 116 p53−/−) and pancreatic cell line Panc-1 (GI50 = 8.6 ± 1.6 μM for compound 131, 8.2 ± 1.2 μM for compound 132). The gene discussed is TP53; the disease is colonic neoplasm.