Studies have shown that Golgi phosphoprotein 3 (GOLPH3L), a highly expressed protein in cancer cells, can stabilize the downstream protein SERPINE1 regulated by p53 to promote glucose metabolism in breast cancer, while miR-1185-2-3p can inhibit the expression of GOLPH3L to prevent the occurrence of breast cancer. The gene discussed is GOLPH3L; the disease is breast cancer.