STUB1 and breast cancer: In addition, Chu et al. used relevant breast cancer data to search for lncRNAs that negatively regulate PGK1, and experimentally confirmed that LncRNALINC00926 downregulates breast cancer cell proliferation and metastasis by enhancing E3 ligase STUB1-mediated ubiquitination of PGK1 and downregulating the level of glycolytic reprogramming in cancer cells.