New robust evidence emerged that COVID-19 vaccination status, obesity, higher HbA1c levels, chronic GLP-1RA use (inversely), pre-existing hypertension, heart failure, liver disease, neuropathy, cancer, the Charlson index, higher levels of CRP, IL-6, AST and LDH, and higher eGFR (inversely) are related to COVID-19-related death and/or COVID-19 severity in people with diabetes. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.