CFL1 and early-onset autosomal dominant Alzheimer disease: Mechanistic function of the cytoskeleton is also important in mammalian systems, as dysfunctions in actin are implicated in age-associated diseases, such as Alzheimer’s Disease (AD): Cofilin, a major actin-binding protein, has been shown to have an impact on several major signature of AD including synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies [4].