As the incidence of RA markedly increases in post-menopausal women (Carlsten, 2005; Sapir-Koren and Livshits, 2017), an increase of the RANK+TLR2+ subset and of α(2,3) sialylation could explain this increased incidence, while also contributing to both joint destruction in RA and osteoporosis in such women. This evidence concerns the gene TNFRSF11A and rheumatoid arthritis.