In this current study, we found that the size of the RANK+TLR2+ subset was greater in the CIA mouse model of RA and that prophylactic treatment with the α(2,3) sialylation inhibitor soyasaponin Bb resulted in significantly less osteoclast formation and joint destruction compared to vehicle-treated CIA mice. This evidence concerns the gene TNFRSF11A and rheumatoid arthritis.