TLR2 and osteoporosis: As the incidence of RA markedly increases in post-menopausal women (Carlsten, 2005; Sapir-Koren and Livshits, 2017), an increase of the RANK+TLR2+ subset and of α(2,3) sialylation could explain this increased incidence, while also contributing to both joint destruction in RA and osteoporosis in such women.