TLR2 and rheumatoid arthritis: As shown above, Maf expression is significantly higher in the RANK+TLR2− subset than the RANK+TLR2+ subset, but in the soyasaponin Bb treatment group we observed Maf expression in the RANK+TLR2+ subset which is significantly greater than Maf expression in the RANK+TLR2+ control or RA groups (Figure 7N), suggesting such expression maintains the RANK+TLR2+ subset in the myeloid lineage and thus reduces their osteoclast differentiation.