AFP and hepatocellular carcinoma: Serum alphafetoprotein has been used as a marker for the effect of postoperative radiation therapy and/or chemotherapy in cases of ovarian endodermal sinus tumours.6 AFP is specific in the yolk sac tumour, but it is not sensitive (overall sensitivity as low as 60%) because it can be seen in other cancers like hepatocellular carcinoma.