ACE2 and Myalgia: One mechanism could be the direct entry of the virus through the ACE-2 receptor and subsequent muscle damage.14 Another mechanism could be related to the spinal ACE2/Ang (1-7)/Mas receptor pathway.15 Yet another hypothesis has proposed the role of interleukin-6 (IL-6) which in turn induces prostaglandin E2 production which results in myalgia.16 Whatever may be the mechanism, myalgia has been found to be a prominent and early symptom of COVID-19 infection.