The results of histological analysis of tumor tissues also indicate that the NPs(siCFL1/Sor) are the most effective in inhibiting tumor growth, as demonstrated by lower expression of CFL1, Nrf2, and PHGDH, more apoptosis (TUNEL), and less proliferation (Ki67) compared to the mice treated with other formulas (Figure 7G). The gene discussed is PHGDH; the disease is neoplasm.