CFL1 and hepatocellular carcinoma: Among these candidate genes, CFL1 is particularly noted as it acts as a hub gene to interact with other six candidate genes and its expression level is negatively correlated with the expression of 30 sorafenib target pathway‐associated DEGs enriched in the GSE109211 dataset (Table S2 and Figure S2, Supporting Information), implying that CFL1 may play an important role in regulating sorafenib sensitivity of HCC patients.