This regulatory mechanism is consistent with a recent study that the Nrf2‐mediated up‐regulation of PHGDH expression could weaken the sensitivity of HCC cells to sorafenib and other sorafenib‐like small molecule drugs.[15] In fact, Nrf2 has been widely recognized as an important regulator of intracellular redox homeostasis. The gene discussed is PHGDH; the disease is hepatocellular carcinoma.