However, as a well‐described m6A demethylase, although AlkB homolog 5 (ALKBH5) was reported to play vital roles in multiple cancers, such as pancreatic cancer,14, 15 intrahepatic cholangiocarcinoma,16 glioblastoma17 and osteosarcoma,18, 19 few studies have ever extensively explored the role of ALKBH5 in CRC. This evidence concerns the gene ALKBH5 and colorectal carcinoma.