The luciferase activities of CRC cells transfected with RAB5A‐WT plasmid, but not the mutant counterpart, obviously decreased in the silence of ALKBH5, and the analogous results would be seen in ALKBH5‐overexpressed cells (Figure 4F), which revealed that the expression of RAB5A mRNA was under the regulation of ALKBH5‐related m6A modification. Here, ALKBH5 is linked to colorectal carcinoma.