Male patients may also have contiguous gene deletion syndrome manifestations, such as intellectual disability, skeletal anomalies, psychomotor abnormalities, gonadal abnormalities, facial deformities, chondrodysplasia punctata (ARSE gene deletion) [49], ichthyosis (STS gene deletion) [50], and other symptoms, which are usually absent or less intense in female patients [3]. The gene discussed is ARSL; the disease is ichthyosis.