The hypertension and lower urinary Na+ excretion found in MST3−/− mice is associated with increased ENaC activity, WNK4 (with-no-lysine 4) expression, and NKCC2 (Na–K-Cl cotransporter) S130 phosphorylation [43], indicating that MST3 participates in maintaining the Na+/K+ homeostasis in response to K+ loading by inhibiting WNK4 expression, NKCC2, and ENaC activity. The gene discussed is SLC12A1; the disease is Hypertension.