In addition to the regulation of insulin signaling, studies have reported that MST3, MST4, and STK25 are exclusively localized around intracellular lipid droplets and increase fat accumulation in human hepatocytes as well as the initiation and progression of nonalcoholic fatty liver disease (NAFLD) [9, 41]. The gene discussed is STK24; the disease is metabolic dysfunction-associated steatotic liver disease.