In addition to the regulation of insulin signaling, studies have reported that MST3, MST4, and STK25 are exclusively localized around intracellular lipid droplets and increase fat accumulation in human hepatocytes as well as the initiation and progression of nonalcoholic fatty liver disease (NAFLD) [9, 41]. This evidence concerns the gene STK26 and metabolic dysfunction-associated steatotic liver disease.