Among them, CCNA2, CENPA, CPE, BRCA2, RFC3, B9D1, RPGR1P1L, NF2, and PSME3 exhibited significantly elevated expression (fold change > 1.5) in the tissues of patients with HCC compared with the normal tissues (Fig. 4B). This evidence concerns the gene BRCA2 and hepatocellular carcinoma.