The results showed that multiple tumor suppressor signatures such as Base excision repair, CD8 + T effector, DNA damage response, DNA replication, Mismatch repair, Nucleotide excision repair and TMEscore were significantly increased in the low-PAMscore group, while EMT, Pan-fibroblast TGF-β response signature (Pan-F-TBRS) and TME inhibited signature of TMEscoreB significantly increased in the high-PAMscore group. The gene discussed is TGFB1; the disease is neoplasm.