GNAS gene was one of the anti‐HER2 therapy resistance‐associated genes reported by Qing et al. who detected seven GNAS variants (p.Arg186His, p.Asp181Gly, p.Asn203Ser, p.Arg216Leu, p.Met206Val, p.Arg216Cys, and p.Asp214Asn) only present in Herceptin-resistant breast cancer patients [33]. Here, ERBB2 is linked to breast carcinoma.