SMAD7 and hepatocellular carcinoma: Previous studies have revealed that SNAI3-AS1 is upregulated in HCC, and can promote tumor cell proliferation and metastasis by activating UPF1/Smad7 signaling pathway and by acting as a sponge for miR-27-3p and miR-34a-5p to upregulate PEG10 [26, 27].