Moreover, the calcified aortic aneurysm tissues of humans and those of murine aneurysm models induced by AngII infusion or CaCL2-soaked gauze contained abundant expressions of CTSK, MMP-9, and tartrate-resistant acid phosphatase (TRAP) that were mainly co-localized in CD11+/TRAP+ osteoclast-like cells [83]. The gene discussed is ACP5; the disease is aortic aneurysm.