A multivariate analysis showed that preoperative intestinal obstruction (HR, 1.734; 95% CI, 1.170–2.568; P = 0.006), PNI (HR, 1.800; 95% CI, 1.353–2.419; P < 0.001), moderate differentiation (HR, 0.689; 95% CI, 0.482–0.985; P = 0.041), N2 stage (HR, 1.976; 95% CI, 1.373–2.844; P < 0.001), M stage (HR, 3.270; 95% CI, 2.319–4.611; P < 0.001), and preoperative CEA level (HR, 1.52;95% CI, 1.120–2.063, P = 0.007) were independent prognostic factors of DFS (Table 4). This evidence concerns the gene CEACAM5 and intestinal obstruction.