CEACAM5 and intestinal obstruction: The multivariate analysis showed preoperative intestinal obstruction (HR, 2.101; 95% CI, 1.393–3.168; P < 0.001), PNI (HR, 1.881; 95% CI, 1.350–2.620; P < 0.001), postoperative chemotherapy (HR, 0.497; 95% CI, 0.351–0.704; P < 0.001), N stage (N1: HR, 1.841; 95% CI, 1.222–2.775; P = 0.004; N2: HR, 2.418; 95% CI, 1.579–3.702; P < 0.001), M stage (HR, 2.311; 95% CI, 1.505–3.550; P < 0.001), preoperative CEA level (HR, 3.005; 95% CI, 1.960–4.608; P = 0.001), preoperative CA 19 − 9 level (HR, 1.597; 95% CI, 1.123–2.270; P = 0.009) are independent prognostic factors for OS (Table 3).