Thus, inhibition of CDK12/13 enhances the sensitivity of HGSOC cells to chemotherapeutic agents already in use for this disease (i.e. Paclitaxel and Olaparib) and uncover new potential vulnerabilities to drugs (i.e. Lapatinib, Trametinib, RAD001, Ceralasertib) that are clinically approved or in trial for other cancer types. Here, CDK12 is linked to cancer.