Based on the PVT1 expression, we stratified TCGA glioma samples by defining tumor in top 25th as higher PVT1 expression group and bottom 25th as lower group, and we found the mutation frequency of IDH1, TP53, CIC, ATRX, EGFR, PTEN, TTN, FUBP1, NOTCH1, SPTA1, KEL, FLG, NF1, RB1, PCLO and AHNAK2 were significant difference among the two group. The gene discussed is EGFR; the disease is central nervous system cancer.